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Qué (quién) es GABAA receptor negative allosteric modulator - definición
GABAA receptor negative allosteric modulator
A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). They are closely related and similar to GABAA receptor antagonists.
GABAA receptor positive allosteric modulator
![Fig 8. R-group position of [[Barbiturates]]](https://commons.wikimedia.org/wiki/Special:FilePath/BarbituratesR groups.jpg?width=200 "Fig 8. R-group position of [[Barbiturates]]")
![Fig 4. GABAergic synapse. The synaptic anchoring protein [[Gephyrin]] is indirectly linked to the GABAA receptors.](https://commons.wikimedia.org/wiki/Special:FilePath/GABA synapse.jpg?width=200 "Fig 4. GABAergic synapse. The synaptic anchoring protein [[Gephyrin]] is indirectly linked to the GABAA receptors.")
![Fig 7. Synthesis and discovery of [[chlordiazepoxide]]](https://commons.wikimedia.org/wiki/Special:FilePath/Synthesis and discovery of chlordiazepoxide.jpg?width=200 "Fig 7. Synthesis and discovery of [[chlordiazepoxide]]")
A SUBSTANCE THAT DOES NOT ACT AS AGONIST OR ANTAGONIST BUT DOES AFFECT THE GAMMA-AMINOBUTYRIC ACID RECEPTOR-IONOPHORE COMPLEX
GABAA receptor positive allosteric modulators; GABAA receptor PAM; GABA modulator; GABA modulators; GABAkine; GABAkines; GABAA receptor potentiator; GABAA receptor potentiators; GABAAR potentiators; GABAAR potentiator; GABA-A receptor potentiator; GABA-A receptor potentiators
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
Allosteric modulator
SUBSTANCE THAT BINDS TO A REGULATORY SITE DISTINCT FROM THE ACTIVE SITE ON A PROTEIN, RESULTING IN CONFORMATIONAL CHANGES THAT MAY INFLUENCE PROTEIN FUNCTION
Allosteric modulation; Positive allosteric modulator; Negative allosteric modulator; Negative allosteric modulation; Positive allosteric modulation; Positive allosteric modulators; Negative allosteric modulators; Positive modulator; Positive modulators; Negative modulator; Negative modulators
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs.
